Game drives in Queen Elizabeth National Park can be split into two areas, the Channel Drive Circuit and the Kasenyi Plains. The Channel Drive Circuit follows the northern shore of the Kazinga Channel, the roads wind between tangled thickets interspersed with the cactus-like euphorbia trees. The most common large mammals seen here are warthog, bush buck, waterbuck, elephants, hippos and frequently lions. Leopards are also a common sight in this section of the park and they occasionally provide a rare opportunity to get up-close with these magnificent animals. This is also one of the few places in Africa where the rare giant forest hog is often seen during daylight hours. The Kasenyi Plains stretching towards Lake George is a typical African Savannah. These rolling plains support some of the largest concentrations of game anywhere in Queen Elizabeth National Park and offer a different selection of animals then that seen on the Channel Drive Circuit. According to local guides, it is said to be the most reliable place in Uganda to see lions. This section of the park alongside the wonderful variety of game and predator species boosts an interesting selection of grassland birds, including grey-crowned crane, red-throated spurfowl and yellow-throated longclaw.

On day 6, drive through the park to the Ishasha sector, where you game drive in search of tree climbing lion, resident herds of endemic Ugandan kob and large herds of buffalo. Arrive at Ishasha Wilderness Camp on the banks of Ntungwe River in time for sunset and a bonfire before dinner.