At 14,000 hectares in size, the Thornybush Private Game Reserve is considered one of the smaller private Kruger Game Reserves. Although it may not be as large as nearby reserves such as Timbavati and Kapama, Thornybush offers an excellent Big 5 wildlife safari experience and has been the setting of choice for many wildlife documentaries. Other feats include having the first recorded white wildebeest born in the wild as well as being one of the first reserves in the Lowveld to start rhino-horn treatments in order to combat poaching.

Under the guidance of expert game rangers, guests can look forward to sighting any number of predator species that call the reserve home including lion, leopard, giraffe, wild dogs, elephant and more totaling 147 mammal species, 114 reptile, 507 bird species, 49 fish and 34 amphibians.